Most Recent Publications
Gerhardt, T. and Landmesser, U. (2025) ‘Advanced understanding of immune mechanisms in acute myocardial infarction: coronary extracellular vesicles trigger NETosis’, European heart journal, vol. 46, no. 10, pp. 940–942.
Yates, A. G., Khamhoung, A., Gaebel, L., Jacob, W., Radford-Smith, D. E., Kiss, M. G., Huynh, P., Gerhardt, T., Heiser, M., Cohen, O., Swirski, F. K., Anthony, D. C., Sumowski, J., Katz Sand, I. and McAlpine, C. S. (2025) ‘Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis’, Nature Communications, vol. 16, no. 1, p. 3683 [Online]. DOI: 10.1038/s41467-025-59074-w 
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Gerhardt, T., Huynh, P. and McAlpine, C. S. (2025) ‘Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis’, Cardiovascular research, vol. 120, no. 18, pp. 2395–2407.
Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Da Ferreira Silva, J., Ameral, N. J., Morgenroth-Rebin, J., D’Souza, D., Koekkoek, L. L., Jacob, W., Munitz, J., Lee, D., Fullard, J. F., van Leent, M. M. T., Roussos, P., Kim-Schulze, S., Shah, N., Kleinstiver, B. P., Swirski, F. K., Leistner, D., St-Onge, M.-P. and McAlpine, C. S. (2024) ‘Myocardial infarction augments sleep to limit cardiac inflammation and damage’, Nature, vol. 635, no. 8037, pp. 168–177 [Online]. DOI: 10.1038/s41586-024-08100-w .
Nelles, G., Abdelwahed, Y. S., Seppelt, C., Meteva, D., Stähli, B. E., Rai, H., Seegers, L. M., Sieronski, L., Musfeldt, J., Gerhardt, T., Riedel, M., Skurk, C., Haghikia, A., Sinning, D., Dreger, H., Knebel, F., Trippel, T. D., Krisper, M., Klotsche, J., Joner, M., Landmesser, U. and Leistner, D. M. (2024) ‘Cholesterol crystals at the culprit lesion in patients with acute coronary syndrome are associated with worse cardiovascular outcomes at two years follow up – results from the translational OPTICO-ACS study program’, International Journal of Cardiology, vol. 399, p. 131665 [Online]. DOI: 10.1016/j.ijcard.2023.131665 .
Horstmann, H., Michel, N. A., Sheng, X., Hansen, S., Lindau, A., Pfeil, K., Fernández, M. C., Marchini, T., Winkels, H., Mitre, L. S., Abogunloko, T., Li, X., Mwinyella, T. B.-N., Gissler, M. C., Bugger, H., Heidt, T., Buscher, K., Hilgendorf, I., Stachon, P., Piepenburg, S., Verheyen, N., Rathner, T., Gerhardt, T., Siegel, P. M., Oswald, W. K., Cohnert, T., Zernecke, A., Madl, J., Kohl, P., Foks, A. C., zur Muehlen, C. von, Westermann, D., Zirlik, A. and Wolf, D. (2024) ‘Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis’, Cardiovascular research, vol. 120, no. 14, pp. 1713–1726.
Seppelt, C., Abdelwahed, Y. S., Meteva, D., Nelles, G., Stähli, B. E., Erbay, A., Kränkel, N., Sieronski, L., Skurk, C., Haghikia, A., Sinning, D., Dreger, H., Knebel, F., Trippel, T. D., Krisper, M., Gerhardt, T., Rai, H., Klotsche, J., Joner, M., Landmesser, U. and Leistner, D. M. (2024) ‘Coronary microevaginations characterize culprit plaques and their inflammatory microenvironment in a subtype of acute coronary syndrome with intact fibrous cap: results from the prospective translational OPTICO-ACS study’, European Heart Journal – Cardiovascular Imaging, vol. 25, no. 2, pp. 175–184 [Online]. DOI: 10.1093/ehjci/jead154 .
Anwari, E., Abdelwahed, Y. S., Seppelt, C., Meteva, D., Gerhardt, T., Musfeldt, J., Sieronski, L., Kraenkel, N., Seegers, L. M., Landmesser, U. and Leistner, D. M. (2024) ‘Arterial stiffness characterization of patients with different ACS-causing plaque morphologies quantified by optical coherence tomography’, European heart journal, vol. 45.
Gerhardt, T., Gerhardt, L. M. S., Ouwerkerk, W., Roth, G. A., Dickstein, K., Collins, S. P., Cleland, J. G. F., Dahlstrom, U., Tay, W. T., Ertl, G., Hassanein, M., Perrone, S. V., Ghadanfar, M., Schweizer, A., Obergfell, A., Filippatos, G., Lam, C. S. P., Tromp, J. and Angermann, C. E. (2023) ‘Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study’, The Lancet Global Health, vol. 11, no. 12, e1874-e1884 [Online]. DOI: 10.1016/S2214-109X(23)00408-4 .
Gerhardt, T., Seppelt, C., Abdelwahed, Y. S., Meteva, D., Wolfram, C., Stapmanns, P., Erbay, A., Zanders, L., Nelles, G., Musfeld, J., Sieronski, L., Stähli, B. E., Montone, R. A., Vergallo, R., Haghikia, A., Skurk, C., Knebel, F., Dreger, H., Trippel, T. D., Rai, H., Joner, M., Klotsche, J., Libby, P., Crea, F., Kränkel, N., Landmesser, U. and Leistner, D. M. (2023) ‘Culprit plaque morphology determines inflammatory risk and clinical outcomes in acute coronary syndrome’, European heart journal, vol. 44, no. 38, pp. 3911–3925 [Online]. DOI: 10.1093/eurheartj/ehad334 .
Gerhardt, T., Stähli, B. E., Rudolph, T. K., Lutz, M., Schatz, A.-S., Zanders, L., Schubert, T., Stueve, M., West, N. E. J., Boone, E., Landmesser, U. and Leistner, D. M. (2023) ‘Prognostic impact of fractional flow reserve measurements in patients with acute coronary syndromes: a subanalysis of the FLORIDA study’, Heart and Vessels, vol. 38, no. 8, pp. 1009–1018 [Online]. DOI: 10.1007/s00380-023-02256-7 .
Meteva, D., Vinci, R., Seppelt, C., Abdelwahed, Y. S., Pedicino, D., Nelles, G., Skurk, C., Haghikia, A., Rauch-Kröhnert, U., Gerhardt, T., Straessler, E., Zhao, Y., Golla, F., Joner, M., Rai, H., Kratzer, A., Arnal, H. G., Liuzzo, G., Klotsche, J., Crea, F., Landmesser, U., Leistner, D. M. and Kränkel, N. (2023) ‘Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study’, European heart journal, vol. 44, no. 38, pp. 3892–3907 [Online]. DOI: 10.1093/eurheartj/ehad379 .
Nelles, G., Abdelwahed, Y. S., Alyaqoob, A., Seppelt, C., Stähli, B. E., Meteva, D., Kränkel, N., Haghikia, A., Skurk, C., Dreger, H., Knebel, F., Trippel, T. D., Krisper, M., Sieronski, L., Gerhardt, T., Zanders, L., Klotsche, J., Landmesser, U., Joner, M. and Leistner, D. M. (2023) ‘Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program’, Atherosclerosis, vol. 385, p. 117284 [Online]. DOI: 10.1016/j.atherosclerosis.2023.117284 .
Gerhardt, T., Monserrat, L., Landmesser, U. and Poller, W. (2022) ‘A novel Troponin I mutation associated with severe restrictive cardiomyopathy-a case report of a 27-year-old woman with fatigue’, European heart journal. Case reports, vol. 6, no. 2, ytac053 [Online]. DOI: 10.1093/ehjcr/ytac053 .
Gerhardt, T., Haghikia, A., Stapmanns, P. and Leistner, D. M. (2021) ‘Immune Mechanisms of Plaque Instability’, Frontiers in Cardiovascular Medicine, vol. 8, p. 797046 [Online]. DOI: 10.3389/fcvm.2021.797046 .
Wolf, D., Gerhardt, T., Winkels, H., Michel, N. A., Pramod, A. B., Ghosheh, Y., Brunel, S., Buscher, K., Miller, J., McArdle, S., Baas, L., Kobiyama, K., Vassallo, M., Ehinger, E., Dileepan, T., Ali, A., Schell, M., Mikulski, Z., Sidler, D., Kimura, T., Sheng, X., Horstmann, H., Hansen, S., Mitre, L. S., Stachon, P., Hilgendorf, I., Gaddis, D. E., Hedrick, C., Benedict, C. A., Peters, B., Zirlik, A., Sette, A. and Ley, K. (2020) ‘Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells’, Circulation, vol. 142, no. 13, pp. 1279–1293.
Kimura, T., Tse, K., McArdle, S., Gerhardt, T., Miller, J., Mikulski, Z., Sidney, J., Sette, A., Wolf, D. and Ley, K. (2017) ‘Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells’, Heart and circulatory physiology, vol. 312, no. 4, H781-H790.
Li, J., McArdle, S., Gholami, A., Kimura, T., Wolf, D., Gerhardt, T., Miller, J., Weber, C. and Ley, K. (2016) ‘CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis’, Circulation research, vol. 118, no. 10, pp. 1540–1552.
Gerhardt, T. and Ley, K. (2015) ‘Monocyte trafficking across the vessel wall’, Cardiovascular research, vol. 107, no. 3, pp. 321–330.
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